I did, even upgrade to Apache 2.4 seems fine in the beginning, it will:
1. broken display when select CWP's PHP info (this will broken too if you just use PHP switcher to PHP7)
2. let's encrypt https stop working and the https sites broken.
Really hope CWP can officially support Apache 2.4, since the current 2.2 will lost support next year. Other critical packages like openssl 1.1.0 and suPHP0.72
Thanks a lot for your efforts.