Outgoing mail stuck in postfix mail queue

All my outgoing mail sent from scripts on the server seem to be hanging in postfix mail queue with connection refused details. Any idea why? I hit process queue and it says done but they are still there.

You'll have to post some queue example error codes and/or relevant log entries. Hard to diagnose anything with such little information...

They are all sitting under deferred in the mail queue. Here is a screenshot of one of them.

160   Recipient address rejected: User unknown in virtual mailbox table
120   Relay access denied
6   Client host rejected: Access denied

This message has an invalid addressee, so you'll have to just delete it or let it bounce back.
160   Recipient address rejected: User unknown in virtual mailbox table

Do you have proper rDNS (reverse DNS / PTR record) set up with your ISP? It is essential for proper mail delivery. Otherwise, you will need a relayhost that will deliver the mail for you.

This message has an invalid addressee, so you'll have to just delete it or let it bounce back.
160   Recipient address rejected: User unknown in virtual mailbox table

Do you have proper rDNS (reverse DNS / PTR record) set up with your ISP? It is essential for proper mail delivery. Otherwise, you will need a relayhost that will deliver the mail for you.

gunstra67@gmail.com exists because it's mine and I get mail there every day. no-reply doesn't exist because I don't want people replying to newsletters. rDNS is setup I've had the data center check it twice niow and in cwp it shows set fine:

Your rDNS for IP 148.163.68.11 is set as following:
vserv.dragonlynx.com

tail the mail logs, that will tell you exactly why